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  • Title: Synthesis and nootropic activity of 2-oxo-1-pyrrolidinesulfonic acid derivatives.
    Author: Cerri A, Farina C, Pinza M, Banfi S.
    Journal: Farmaco; 1991; 46(7-8):959-66. PubMed ID: 1793478.
    Abstract:
    The synthesis of a series of 2-oxo-1-pyrrolidinesulfonic acid derivatives, as potential nootropic agents, is reported. Such compounds were designed to have chemical and physico-chemical properties intermediate between 2-oxo-1-pyrrolidineacetamides (e.g. oxiracetam) and 1-acyl-2-pyrrolidinones (e.g. aniracetam). The ability of these compounds to counteract the ECS-induced amnesia in mice was assessed in a one trial, step through, passive avoidance paradigm. Whilst oxiracetam and aniracetam confirmed their antiamnestic action, none of the title compounds showed a statistically significant activity.
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