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  • Title: Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix.
    Author: Romanelli M, Dini V, Romanelli P.
    Journal: Arch Dermatol; 2007 Oct; 143(10):1310-3. PubMed ID: 17938346.
    Abstract:
    BACKGROUND: The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion. OBSERVATIONS: We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity. CONCLUSION: This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers.
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