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  • Title: Effect of propofol on mucous permeability and inflammatory mediators expression in the intestine following traumatic brain injury in rats.
    Author: Sun J, Wang L, Shen J, Wang Z, Qian Y.
    Journal: Cytokine; 2007 Nov; 40(2):151-6. PubMed ID: 17942318.
    Abstract:
    AIM: To explore whether propofol could in vivo, suppress intestinal permeability and proinflammatory cytokines in the intestine after traumatic brain injury (TBI). METHODS: The rats were randomly divided into four groups including control group with right parietal bone window alone and no brain injury, TBI group, TBI+propofol (5mg/kg/h), and propofol alone group. All animals were killed 72h later. Plasma endotoxin was assayed by the chromogenic limulus amebocyte lysate test. Intestinal permeability was quantified using the lactulose/mannitol (L/M) test. TNF-alpha and IL-6 in the intestine were measured using commercially available enzyme-linked immunoassay Kits. Nuclear factor kappa B (NF-kappaB) was analyzed by Electrophoretic mobility shift assay (EMSA). RESULTS: No rats died before sacrifice. Plasma endotoxin, L/M ratio, intestinal level of NF-kappaB, TNF-alpha, and IL-6 remained at baseline level in controlled animals. TBI promoted a significant increment in plasma endotoxin, L/M ratio, intestinal level of NF-kappaB, TNF-alpha, and IL-6. Propofol inhibited those parameters at the dose of 5mg/kg/h. CONCLUSION: Propofol has the protective effect on the intestine following traumatic brain injury in rats.
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