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  • Title: [The effect of cyclovirobuxinum D on myocardial ischemia induced by coronary artery ligation in rats].
    Author: Zhou JY, Sun YD, Tan YH, Deng SJ, Huang GY.
    Journal: Zhong Yao Cai; 2007 Jul; 30(7):828-30. PubMed ID: 17944197.
    Abstract:
    OBJECTIVES: To study the cardiac protection of Cyclovirobuxinum D (Cvb-D) in rats model. METHODS: The rats were subjected to left main coronary artery occlusion. The change about S-T segment, the area of myocardial injury (necrotic and ischemic areas), the amount of cardiac tissue malondialdehyde (MDA), the cardiactissue creatine phosphokinase (CPK) and the cardiac tissue superoxide dismutase (SOD) activation were measured. RESULTS: Compared to the model group, Cvb-D (1.1 mg/kg, 2.2 mg/kg dos-age) significantly reduce myocardial damage, reduce myocardial ischemia mode rats' sigma s-t of ECG, significantly reduce cardiac tissue CPK activation and MDA content, raise the cardiac tissue SOD activation in the rats with myocardial ischemia. CONCLUSION: Cvb-D is effective in treatment of myocardial ischemia in rats.
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