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  • Title: [Synthesis and antibacterial activity of N-(aroylalkyl) ciprofloxacin].
    Author: Hu AX, Wang YT, You TB.
    Journal: Yao Xue Xue Bao; 2007 Aug; 42(8):854-7. PubMed ID: 17944234.
    Abstract:
    In order to obtain the drugs with broader antibacterial spectrum, better antibacterial effect and less side-effect, modifications with lipid solublity group at the position of piperazinyl of ciprofloxacin 13C NMR, ESI-MS and elemental analysis. The lipid solublility of the new compounds was better than that of ciprofloxacin. The results of antibacterial activity in vitro showed that most of the target compounds possessed relatively high inhibiting activity on Escherichia coli and Pseudomonas aeruginosa. The antibacterial activity of the target compound 3d was higher than that of ciprofloxacin against Escherichia coli.
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