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  • Title: Developmental changes in expression of adhesion-mediating proteins in human aortic smooth muscle.
    Author: Koteliansky VE, Belkin AM, Frid MG, Glukhova MA.
    Journal: Biochem Soc Trans; 1991 Nov; 19(4):1072-6. PubMed ID: 1794465.
    Abstract:
    Phenotypic variability of vascular smooth muscle cells (SMCs) can serve as a good model for studying the mechanisms regulating the expression of adhesion-mediating proteins. To describe phenotypic changes of human aortic SMCs, we have studied the expression of cytodifferentiation-related adhesion-mediating proteins in samples of media from fetal, child and adult human aorta, and in subendothelial intima of normal and atherosclerotic aorta. We have shown that during prenatal and post-natal development vascular SMCs co-ordinately change several times the expression of certain differentiation-related proteins. Our data show the existence of certain groups of proteins whose expression during smooth muscle development might be controlled by two basic mechanisms: selection of genes to be expressed at particular developmental stages and generation of several different protein variants from a single gene via alternative RNA splicing.
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