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  • Title: [Ab-interno sclerostomy with the excimer laser via a quartz fiber in albino rabbits].
    Author: Müller-Stolzenburg N, von Haebler M, Buchwald HJ, Bergmann AJ, Kruse HA, Müller GJ.
    Journal: Fortschr Ophthalmol; 1991; 88(6):762-9. PubMed ID: 1794799.
    Abstract:
    After attempting to induce experimental glaucoma in 20 albino rabbits by topical administration of 0.1% dexamethasone, ab-interno sclerostomy with an excimer laser at 308 nm via a quartz fiber was performed in one eye of each animal. Preoperatively, the sclera was stained with a UV-absorbing drug (sulfisomidine) in 10 rabbits; to shield the lens from scattered radiation, another UV absorber (fluorescein) was injected additionally into the anterior chamber. The other 10 rabbits were operated on without pretreatment. A full-thickness sclerostomy was performed in all animals. Most of the eyes upon operated showed minimal inflammation in the first few postoperative days. The intraocular pressure in the operated eyes was reduced compared to the fellow eye for about 3 months. Histology showed a 50-microns broad, smooth, thermally damaged zone at the edges of the sclerostomy. Clinical and histological investigation showed no evidence of UV-induced damage on the lens or retina in either group. Application of the UV absorber led to a significant decrease in the number of pulses required to perforate the sclera, but had no influence on the clinical history.
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