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  • Title: Effect of alcohols and their potentiating responses on acetylcholine induced contractures on frog rectus abdominis.
    Author: Kela AK, Srivastava AK, Tripathi CD, Mehta SC.
    Journal: Indian J Exp Biol; 1991 Sep; 29(9):849-51. PubMed ID: 1794869.
    Abstract:
    Ethanol, propanol and butanol cause contraction and potentiate the responses of acetylcholine (Ach) on frog's rectus muscle. These actions are minimum with ethanol and maximum with butanol. Various drugs acting at different levels of neuromuscular transmission inhibited the responses of alcohol itself and also its potentiating responses of Ach. The results show that these effects are partly due to enhanced release of Ach at neuromuscular junction and partly due to release of sarcoplasmic calcium suggesting that more than one mechanism may be responsible for these actions.
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