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  • Title: Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn2+ in aqueous solution.
    Author: Joshi BP, Cho WM, Kim J, Yoon J, Lee KH.
    Journal: Bioorg Med Chem Lett; 2007 Dec 01; 17(23):6425-9. PubMed ID: 17949975.
    Abstract:
    A new fluorescent peptide probe for the detection of Zn(2+) was synthesized on the basis of zinc binding ligands in zinc enzymes. The peptide that has a unique amino acid sequence displayed a great selectivity for Zn(2+) in the presence of several transition metal ions in aqueous solution. The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied. Further, on-bead application of the peptide as chemosensors was demonstrated.
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