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  • Title: Acral erythema with oral methotrexate in a child.
    Author: Varela CR, McNamara J, Antaya RJ.
    Journal: Pediatr Dermatol; 2007; 24(5):541-6. PubMed ID: 17958806.
    Abstract:
    Acral erythema is a rare cutaneous reaction that has been associated with various chemotherapy regimens. Most occurrences have been described in adult patients. Recently, methotrexate has been implicated in the development of acral erythema; however, pediatric reports are few. All of the reports in the pediatric and adult literature have described patients receiving moderate to high-dose intravenous methotrexate. Here, we describe an instance of standard-dose oral methotrexate-associated acral erythema in a young girl with acute lymphoblastic leukemia, and review the recent literature as it relates to pediatric patients.
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