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  • Title: [Inhibitory effect of polysaccharides on the six-alpha-helix bundle formation of HIV gp41 protein].
    Author: Wen XY, Wu SY, Xu W, Lv L, Liu SW, Rao JJ, Zhang JJ, Wang GF, Wan SH, Wu SG.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2007 Oct; 27(10):1498-500. PubMed ID: 17959523.
    Abstract:
    OBJECTIVE: To compare the in vitro inhibitory effect of expolysaccharides from Streptomyces, polysaccharides of Ganoderma lucidum and rice bran on six-alpha-helix bundle formation of HIV gp41 protein. METHODS: The amount of six-alpha-helix bundle formed in the presence of N36 and C34 was tested by ELISA in response to treatments with different doses of polysaccharides. RESULTS: Expolysaccharides from Streptomyces potentially inhibited six-alpha-helix bundle formation with the effective concentration (IC(50)) of 145.48-/+7.25 mg /L. Polysaccharides of Ganoderma lucidum and rice bran showed no effect on the six-alpha-helix bundle formation. CONCLUSION: Expolysaccharides from Streptomyces can inhibit the six-alpha-helix bundle formation of HIV gp41, whereas polysaccharides of Ganoderma lucidum and rice bran do not exhibit such activity.
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