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  • Title: [Clinical and pathological characteristics of patients with glomerular hematuria as the major manifestation].
    Author: Wan X, Zhang YM, Liu W, Huang HH, Li JG.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2007 Oct; 27(10):1561-3. PubMed ID: 17959537.
    Abstract:
    OBJECTIVE: To compare the clinical and pathological characteristics between patients with and without glomerular hematuria. METHODS: Totally 310 patients with isolated microscopic hematuria and 24-hour urinary protein <0.5 g were enrolled in this study, who were free of renal calculi, infections, or tumors. These patients were divided into glomerular hematuria group and non-glomerular hematuria group according examination by phase-contrast microscope, and their clinicopathological data were retrospectively analyzed. RESULTS: Of the 209 patients identified to have glomerular hematuria, 46.41% had IgA nephropathy, 22.49% had small glomerular lesions, and 14.35% had non-IgA mesangioproliferative glomerulonephritis. In the patients with non-glomerular hematuria, 65.34% had IgA nephropathy, 21.78% had non-IgA mesangioproliferative glomerulonephritis, and 8.91% had small glomerular lesions. No significant differences were found in the patients' gender, age, course of disease or hypertension between the two groups (P>0.05), but renal insufficiency was more common in patients with glomerular hematuria. CONCLUSION: IgA nephropathy is still the most frequent pathological finding in patients with hematuria, and even in non-glomerular hematuria patients severe renal pathological changes can be common.
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