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  • Title: Analysis of hTERT expression in exfoliated cells from patients with bladder transitional cell carcinomas using SYBR green real-time fluorescence quantitative PCR.
    Author: Xie XY, Yang X, Zhang JH, Liu ZJ.
    Journal: Ann Clin Biochem; 2007 Nov; 44(Pt 6):523-8. PubMed ID: 17961306.
    Abstract:
    AIMS: To investigate whether hTERT mRNA expression could be used as a diagnostic and prognostic marker of bladder transitional cell carcinoma. METHODS: SYBR green I real-time fluorescence quantitative PCR method was used to quantify hTERT mRNA expression in exfoliated cells from patients with bladder transitional cell carcinomas. RESULTS: A significant correlation was observed between the level of hTERT mRNA expression in exfoliated cells collected in urine with pathological grade and clinical stage. CONCLUSIONS: Our results show that SYBR green real-time fluorescence quantitative evaluation of hTERT mRNA could be a useful marker of tumor progression for the early diagnosis and prognosis of bladder cancers.
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