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  • Title: [Study on parental origin of complete hydatidiform mole detected by polymorphisms of microsatellite].
    Author: Deng SS, Ding ZM, Qian JH, Lü WG, Wan XY, Xie X.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2007 Jul; 42(7):468-71. PubMed ID: 17961337.
    Abstract:
    OBJECTIVE: Through detection of 9 loci of polymorphisms of microsatellite to investigate the parental origin of complete hydatidiform mole. METHODS: Using the technology and method of multipolymerase chain reaction and electrophoresis in denatured polyacrylamide gel and silver stain detection, we carried out DNA analysis on 50 cases of complete hydatidiform mole diagnosed by histopathology and 50 copies of the couples' peripheral blood. RESULTS: There are 7 cases of biparental complete hydatidiform mole (14%); and 43 cases of androgenetic complete hydatidiform mole (86%) among 50 cases of complete hydatidiform mole. CONCLUSIONS: Detection of polymorphisms of microsatellite is a technology that can be used to identify the parental origin of complete hydatidiform mole. It is simple, quick, reliable and highly efficient.
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