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  • Title: Hemoglobin F in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project report.
    Author: Krous HF, Haas EA, Chadwick AE, Masoumi H, Stanley C, Perry GW.
    Journal: J Forensic Leg Med; 2007 Nov; 14(8):456-60. PubMed ID: 17961870.
    Abstract:
    Whether levels of fetal hemoglobin (HbF), a possible marker of antecedent hypoxemia, are increased in sudden infant death syndrome (SIDS) compared to controls is unresolved. Our aims are to: (1) Compare percent fetal hemoglobin (%HbF) levels in SIDS and control cases, and (2) compare our findings with those reported in previous studies. Using Triton-acid-urea gel electrophoresis and quantitative densitometry, %HbF was determined in whole blood specimens obtained at autopsy from SIDS and control cases accessioned into the San Diego SIDS/SUDC Research Project database. The SIDS and control cases were not different with respect to mean age, gender, gestational age, method of delivery, birth weight, or mean autopsy interval; %HbF levels in SIDS and control cases were not significantly different. Given that our results were obtained using optimal methods in well-defined SIDS and control cases, we concur with others that %HbF is not elevated in SIDS.
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