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  • Title: Performance of four mixed-mode solid-phase extraction columns applied to basic drugs in urine.
    Author: Klinke HB, Linnet K.
    Journal: Scand J Clin Lab Invest; 2007; 67(7):778-82. PubMed ID: 17963158.
    Abstract:
    Four different mixed-mode cation exchange solid-phase extraction columns were compared for extraction of basic drugs from urine using HPLC-DAD analysis: Isolute HCX-3, ABN, Bond Elut Certify and Oasis MCX. With one exception, all the studied drugs attained recoveries exceeding 50 % for all columns. We considered the following drugs: amphetamine, amlodipine, chlorprothixene, fentanyl, haloperidol, ketobemidone, methadone, mirtazapine, olanzapine, quetiapine, sertraline and zopiclone. The average recoveries for the four column types ranged from 68.5 % to 92.1 % in the experiments. In conclusion, the basic compounds performed reasonably well in all columns, and other factors, such as availability and price, may be decisive in regard to choice of column.
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