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  • Title: [Central neural mechanism underlying pressor response to excitation of locus coeruleus in rats].
    Author: Zhou CJ, Zou X, Ku YH.
    Journal: Sheng Li Xue Bao; 1991 Dec; 43(6):556-64. PubMed ID: 1796319.
    Abstract:
    Experiments were done on urethane anesthetized, tubocurarine immobilized and artificially ventilated rats and the following results were observed: (1) Injection of sodium L-glutamate (Glu) into locus coeruleus (LC) could evoke a pressor response, but heart rate was not significantly affected; while depressor and bradycardia effects were observed when injecting into closely adjacent areas. (2) The LC-pressor response decreased after a brain transection caudal to nucleus paraventricularis was made but remained unchanged if the transection was rostral to the nucleus; The LC-pressor response could also be attenuated by preinjection of phentolamine propranolol or atropine respectively into the rostral ventrolateral medulla (RVL). The above results suggest that LC-pressor response is not only mediated by RVL, but also by nucleus paraventricularis.
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