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  • Title: [Hemodialysis in children and beta 2-microglobulin].
    Author: Jovanović O, Mirić-Nastić D, Nikolić G, Dimitrijević N, Popović-Rolović M.
    Journal: Srp Arh Celok Lek; 1991; 119(3-4):77-82. PubMed ID: 1796332.
    Abstract:
    Retention of beta-2-microglobulin, due to loss of excretory renal function inevitably occurs in uremia. A significant correlation between the duration of hemodialysis and the incidence of carpal tunnel syndrome or destructive cystic lesions of bone has been reported. Amyloid deposition has been found to directly cause these lesions. This amyloid protein has been identified to be beta-2-microglobulin. The aim of this report was to study plasma beta-2-microglobulin levels in hemodialysed children and to detect clinical manifestations or carpal tunnel syndrome and of bone lesions. 12 children aged 9-24 years were studied. The average duration of dialysis was 51.9 ae 32 months. Beta-2-microglobulin plasma levels were studied before and after hemodialysis treatment. All patients were examined for carpal tunnel syndrome using clinical methods including nerve conduction studies, and for destructive cystic lesions using X-rays of bone. Plasma beta-2-microglobulin concentrations in our patients were found to be sevrefold time higher (73.8 ae 22.1 mg/l) than control values (1.6 ae 0.5 mg/l). The increase of beta-2-microglobulin concentration during hemodialysis tratment was due probably by hemoconcentration. We noted poor correlation between plasma beta-2-microglobulin and duration of hemodialysis. Any signs of carpal tunnel syndrome was found to our patients. Radiological signs of amyloid osteopathy found to be present in 3 children, was not verified by bone biopsy.
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