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  • Title: Calcium phosphate phase transformation produced by the interaction of the portland cement component of white mineral trioxide aggregate with a phosphate-containing fluid.
    Author: Tay FR, Pashley DH, Rueggeberg FA, Loushine RJ, Weller RN.
    Journal: J Endod; 2007 Nov; 33(11):1347-51. PubMed ID: 17963961.
    Abstract:
    The bioactivity of mineral trioxide aggregate (MTA) has been attributed to its ability to produce hydroxyapatite in the presence of phosphate-containing fluids. It is known that stoichiometric hydroxyapatites do not exist in biological systems and do not contribute to the osteogenic potential of calcium phosphate-based biomaterials. Because Portland cement is the active ingredient in white MTA, we have characterized the calcium phosphate phases produced when set white Portland cement was immersed in phosphate-buffered saline using pH and turbidity measurements, scanning electron microscopy, energy dispersive X-ray analysis, transmission electron microscopy, electron diffraction, x-ray diffraction, and Fourier transform-infrared spectroscopy. An amorphous calcium phosphate phase was initially formed that transformed to an apatite phase, with the latter consisting of calcium-deficient, poorly crystalline, B-type carbonated apatite crystallites. Amorphous calcium phosphate is a key intermediate that precedes biological apatite formation in skeletal calcification. Thus, the clinical manifestations of bioactivity with the use of MTA may at least be partially attributed to the mineralization induction capacity of its Portland cement component.
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