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  • Title: Discovery of small-molecule inhibitors of tyrosinase.
    Author: Germanas JP, Wang S, Miner A, Hao W, Ready JM.
    Journal: Bioorg Med Chem Lett; 2007 Dec 15; 17(24):6871-5. PubMed ID: 17964155.
    Abstract:
    To identify novel inhibitors of tyrosinase, a fluorescent assay was developed which is suitable for high-throughput screening. In the assay, oxidation of the substrate by tyrosinase leads to the release of a fluorescent coumarin. Several small molecules were identified that inhibited mushroom tyrosinase in vitro and human tyrosinase in cell culture. These compounds may represent lead structures for therapies targeted at disorders of hyperpigmentation.
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