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  • Title: [Morphological and biochemical study of the organs of immunogenesis during the growth of established glioblastoma multiforme in albino rat brain].
    Author: Bezuglova TV, Iurkiv VA.
    Journal: Biull Eksp Biol Med; 1975 Jul; 80(7):84-8. PubMed ID: 179646.
    Abstract:
    Morphological changes in the lympho-reticular organs (the thymus, lymph nodes, spleen) were studied and the content of the RNA was determined by the biochemical method in 92 rats during the growth of the glioblastoma multiforme (strain 101/12) in the brain. The reaction of the organs of immunogenesis depended on the stage of the disease. On the 6th day after the transplantation of the tumour the increased activity of the epithelial-reticular portion of the thymus, hyperplasia of the follicles in the lymph nodes, and increased produciton of the RNA was observed. As to the tumour-bearing animals the destruction of the lymphoid elements and decreased synthesis of the RNA was noted. A giradual cell depletion of the spleen was revealed morphologically.
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