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  • Title: [Changes in the amount of 3H-thymidine label in hepatocytes of different ploidies in rat ontogeny after a single administration of the isotope].
    Author: Shteĭn GI, Malev VV, Kudriavtsev BN.
    Journal: Tsitologiia; 1991; 33(5):31-8. PubMed ID: 1796518.
    Abstract:
    Change of 3H-thymidine quantity in mono- and binuclear rat hepatocytes of different ploidy was investigated during the first 6 weeks after a single injection of isotope to newborn rats. Rates of cell transitions (arbitrary number of cells in the time unit) from one ploidy class to another, and coefficients of the reducing of hepatocyte proliferative activity with increasing the hepatocyte ploidy were calculated on the basis of ideas about the process of autoradiographic label "diluting" in the course of the postnatal development as a result of polyploidization and ordinary mitotic divisions of hepatocytes. The calculated values are close to values of parameters, which were calculated with assistance of the model, which describes the process of polyploidization in the liver, on the basis of data on the change in the arbitrary number of different ploidy hepatocytes.
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