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  • Title: UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese.
    Author: Honda M, Toyoda W, Shimizu T, Horiuchi I, Kayano Y, Taguchi M, Nozawa T, Inoue H, Hashimoto Y.
    Journal: Drug Metab Pharmacokinet; 2007 Oct; 22(5):382-6. PubMed ID: 17965522.
    Abstract:
    We previously investigated the pharmacokinetics of R- and S-carvedilol in 54 healthy Japanese subjects, and reported that the oral clearance (CL/F) and apparent volume of distribution (V/F) of both enantiomers in subjects with the CYP2D6*10 allele were significantly lower than those in subjects without the CYP2D6*10 allele. In the present study, we examined the genotype of UGT2B7 in these 54 subjects, and investigated the effect of UGT2B7*3 on the pharmacokinetics of R- and S-carvedilol. Forty-three subjects did not have the UGT2B7*3 allele, and 11 subjects had one UGT2B7*3 allele. CL/F and V/F values of R- and S-carvedilol in the subjects with one UGT2B7*3 allele were similar to those without the UGT2B7*3 allele, indicating that the UGT2B7*3 allele did not significantly affect the systemic clearance (CL) and bioavailability (F) of the two enantiomers.
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