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  • Title: [Expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance].
    Author: Zhang L, Jing Y, Yu L.
    Journal: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Aug; 21(15):692-4. PubMed ID: 17969521.
    Abstract:
    OBJECTIVE: To evaluate expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance. METHOD: The immunohistochemical method and the in situ hybridization were employed in detecting the NF-kappaB p65 expressions in surgical specimen from 48 laryngeal carcinoma and 20 normal mucous membrane. RESULT: (1) The expression of NF kappaB p65 was higher than in normal laryngeal mucous membrane. (2) Positive expression of NF-kappaB p65 correlated with the development of distant metastasis. CONCLUSION: The results of the study show that the NF-kappaB p65 protein is a significant predictor of survival in laryngeal carcinoma patients.
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