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  • Title: Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
    Author: Newsome JJ, Colucci MA, Hassani M, Beall HD, Moody CJ.
    Journal: Org Biomol Chem; 2007 Nov 21; 5(22):3665-73. PubMed ID: 17971996.
    Abstract:
    A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.
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