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  • Title: Surfactant protein D in Pseudomonas aeruginosa keratitis.
    Author: McCormick CC, Hobden JA, Balzli CL, Reed JM, Caballero AR, Denard BS, Tang A, O'Callaghan RJ.
    Journal: Ocul Immunol Inflamm; 2007; 15(5):371-9. PubMed ID: 17972221.
    Abstract:
    PURPOSE: To determine the importance of surfactant protein D in Pseudomonas keratitis. METHODS: The surfactant D status of wild-type and surfactant D-deficient Black Swiss mice was confirmed by PCR reactions and immunoblot assay. Mouse corneas were infected with one of three strains of P. aeruginosa. At 1, 2, 3, and 6 days postinfection, eyes were scored by slit-lamp examination and bacteria per cornea quantified. RESULTS: Infected wild-type mice had slit-lamp scores on 3 and 6 days postinfection that were significantly lower than those of surfactant D-deficient mice (p <or= .0185) and only wild-type mice recovered from the infection. On day 6 postinfection, the number of bacteria per cornea was found to be significantly lower in wild-type mice as compared to surfactant D-deficient mice (p <or= .0233). CONCLUSIONS: Surfactant D is important to the ocular innate host defense against Pseudomonas keratitis.
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