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  • Title: Expression of vascular endothelial growth factor in salivary gland carcinomas correlates with lymph node metastasis.
    Author: Lequerica-Fernández P, Astudillo A, de Vicente JC.
    Journal: Anticancer Res; 2007; 27(5B):3661-6. PubMed ID: 17972532.
    Abstract:
    BACKGROUND: Carcinomas of the salivary glands are uncommon heterogeneous tumors characterized by locoregional invasion and distant metastasis. Angiogenesis is a necessary condition for invasion and metastasis, and vascular endothelial growth factor (VEGF) is considered a prime mediator of this process. The relationship between VEGF and clinical outcome in cancers of diverse locations has been examined, yielding inconclusive results. PATIENTS AND METHODS: An immunohistochemical study was conducted on the expression of VEGF protein in 66 salivary gland carcinomas and the relation between VEGF and clinicopathological parameters explored. RESULTS: VEGF expression was seen in 41 tumors (62%) and was correlated with lymph node metastasis (p<0.005), clinical stage (p<0.02), cause-specific survival (p<0.01) and local failure-free survival (p<0.02). CONCLUSION: VEGF can contribute to the progression of salivary gland carcinomas and seems to be associated with neck node metastasis, worse survival and poor local control of the disease.
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