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  • Title: [Successive appearance of chronic lymphocytic leukaemia and Hodgkin's lymphoma in the same patient].
    Author: Kovcin V, Jelić S, Jovanović V.
    Journal: Srp Arh Celok Lek; 1994; 122(11-12):350-3. PubMed ID: 17974418.
    Abstract:
    The article deals with a patient treated for multiple apitheliomas and chronic lymphocytic leukaemia. Chronic lymphotic leukaemia was diagnosed on the basis of clinical, haematologic and hstopathologic findings, when all lymphocytes in the lymph gland were reactive to monoclonic antibody pan-B and negative to pen-T and Leu-M1. Chemotherapy was ordinated. Unexpectadly, after three cycles of therapy the complate clinical, haematologic and immunologic remission of the disease occurzed. Nine months later the enlarged exillary glands appeared. By histological analysis the Hodgkin's syndrome was diagnosed. It was of mixed cellularity, with mixed lymphocytes population that reacted to monoclonic antibodies pan-B and pan-T, and with Reed-Sternberg's cells reactive to Leu-M1. In time of diagnosing the Hodgkin's syndrome no sign of chronic lymphocytic leukaemia existed. After two cycles of chemotherapy the total remission of Hodgkin's lymphoma was established. Two years later, the patient presented the complete remission of both lymphomas.
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