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  • Title: Evaluation of some adamantane-based synthetic trioxanes against Plasmodium knowlesi in rhesus monkeys.
    Author: Tripathi R, Mishra D, Rizvi A, Singh C.
    Journal: Life Sci; 2007 Nov 10; 81(21-22):1544-8. PubMed ID: 17976659.
    Abstract:
    In our search for synthetic substitutes for artemisinin and its derivatives we had earlier prepared a series of adamantane-based 1, 2, 4-trioxanes 5a-c which had shown promising activity against P. berghei in Swiss mice. We have further evaluated these and two new compounds (5d-e) against Plasmodium knowlesi W1, a virulent malaria parasite in rhesus monkeys, in the dose range of 40-80 mg/kg x 5 days by intramuscular route. Trioxanes 5b and 5c showed 100% protection and cure at 80 mg/kg x 5 days, while trioxane 5a showed 71% cure at this dose. Detailed studies again showed 50% curative effect of 5a at 40 mg/kg x 5 days treatment.
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