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  • Title: Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers.
    Author: Thomas TJ, Pauze D, Love JN.
    Journal: J Emerg Med; 2008 Jan; 34(1):71-5. PubMed ID: 17976801.
    Abstract:
    Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view. Fatalities associated with diphenoxylate-atropine have been reported in toddlers after repetitive or incorrect dosages. Fortunately, trends in pediatric diphenoxylate-atropine ingestions are decreasing. We review the management, trends, and current concepts regarding pediatric diphenoxylate-atropine ingestions.
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