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  • Title: Analysis of 1,1'-sulphonylbis[2-(methylsulphinyl)ethane] and 1-methylsulphinyl-2-[2-(methylthio)ethylsulphonyl]ethane, metabolites of sulphur mustard, in urine using gas chromatography-mass spectrometry.
    Author: Black RM, Clarke RJ, Read RW.
    Journal: J Chromatogr; 1991 Oct 11; 558(2):405-14. PubMed ID: 1797814.
    Abstract:
    A method has been developed for the detection of 1,1'-sulphonylbis[2-(methylsulphinyl)ethane] and 1-methylsulphinyl-2-[2-(methylthio)ethylsulphonyl]ethane, which have been identified as urinary metabolites of sulphur mustard in the rat. The two metabolites were reduced to the single analyte 1,1'-sulphonylbis[2-(methylthio)ethane] by treatment of urine with acidic titanium trichloride. 1,1'-Sulphonylbis[2-(methylthio)ethane] was readily extracted from urine by passing through a C8 reversed-phase extraction column, or by solvent extraction from a solid absorbent tube, and detected by gas chromatography-mass spectrometry using ammonia positive ion chemical ionisation. The limit of detection was 2 ng/ml for 1-ml samples of urine. There were no background levels of analyte in human or rat urine. If man metabolises sulphur mustard by a similar pathway, the detection of these metabolites should constitute firm evidence of an exposure to sulphur mustard.
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