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  • Title: Allosteric activation of a bacterial stress sensor.
    Author: Yan N, Shi Y.
    Journal: Cell; 2007 Nov 02; 131(3):441-3. PubMed ID: 17981109.
    Abstract:
    In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.
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