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  • Title: The influence of basal phenotype on the metastatic pattern of breast cancer.
    Author: Luck AA, Evans AJ, Green AR, Rakha EA, Paish C, Ellis IO.
    Journal: Clin Oncol (R Coll Radiol); 2008 Feb; 20(1):40-5. PubMed ID: 17981444.
    Abstract:
    AIMS: To assess whether basal phenotype influences the metastatic pattern and survival in patients with metastatic breast cancer. MATERIALS AND METHODS: The basal phenotype status of a well-characterised series of consecutive primary operable breast cancers (1868 cases) was ascertained using the basal cytokeratin markers CK5/6 and CK14. Follow-up data, including time, site and pattern of distant metastasis and post-metastasis survival, were available for 113 women with basal phenotype cancers and they were compared with 178 matching cases from women in the non-basal phenotype group. RESULTS: Patients with basal phenotype were more likely to present with intrapulmonary (25/48, [52%] vs 15/64, [23%]; P=0.0009) and/or brain metastases (20/113, [18%] vs 3/178, [2%]; P<0.0001) than non-basal phenotype patients. Patients with non-basal phenotype were more likely to present with bone metastases in the absence of visceral disease (48/102, [47%] vs 14/62, [23%]; P=0.0017) than patients with basal phenotype. There was no significant difference in the frequency of pleural or liver metastases between both groups. Basal phenotype was also associated with a shorter median survival with metastatic disease (10.1 months vs 25 months, P<0.001). The multivariate analysis, including other established prognostic variables in breast cancer, showed that basal phenotype is an independent poor prognostic factor. CONCLUSION: Intrapulmonary and brain metastases are seen more frequently at metastatic presentation in basal phenotype breast cancer patients, and the basal phenotype is associated with a poorer survival after metastatic presentation. Assessment of basal cytokeratin expression status may provide valuable prognostic information relevant to breast cancer patients' management.
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