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  • Title: Intraperitoneal injection of cholecystokinin elicits sleep in rabbits.
    Author: Kapás L, Obál F, Opp MR, Johannsen L, Krueger JM.
    Journal: Physiol Behav; 1991 Dec; 50(6):1241-4. PubMed ID: 1798781.
    Abstract:
    Cholecystokinin (CCK) reduces food intake and promotes non-rapid-eye-movement sleep (NREMS) in rats. The purpose of present experiments was to determine if CCK is somnogenic in rabbits; another species in which CCK suppresses feeding. White New Zealand rabbits were treated intracerebroventricularly (ICV; 0.05, 0.5 and 2 micrograms) or intraperitoneally (IP; 2.5, 10 and 40 micrograms/kg) with CCK or saline, and sleep-wake activity and brain temperature (Tbr) were recorded for 6 h. Injections of 10 and 40 micrograms/kg CCK IP elicited a decrease in wakefulness and an increase in NREMS during the first hour postinjection. The hypnogenic effects were accompanied by a decrease in Tbr. After the IP injection of a lower dose (2.5 micrograms/kg) a slight, nonsignificant increase in NREMS during the first hour postinjection was followed by a decrease in NREMS. ICV injections of CCK had relatively small inhibitory effects on sleep. We conclude that circulating, hormone CCK might be a hypnogenic signal with a peripheral site of action.
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