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  • Title: Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity.
    Author: Nam SJ, Ko H, Ju MK, Hwang H, Chin J, Ham J, Lee B, Lee J, Won DH, Choi H, Ko J, Shin K, Oh T, Kim S, Rho JR, Kang H.
    Journal: J Nat Prod; 2007 Nov; 70(11):1691-5. PubMed ID: 17988093.
    Abstract:
    Three new scalarane-based sesterterpenes, 1- 3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC50 values of 2.4 and 24 microM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.
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