These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Psammaplysenes C and D, cytotoxic alkaloids from Psammoclemma sp.
    Author: Buchanan MS, Carroll AR, Addepalli R, Avery VM, Hooper JN, Quinn RJ.
    Journal: J Nat Prod; 2007 Nov; 70(11):1827-9. PubMed ID: 17988096.
    Abstract:
    The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.
    [Abstract] [Full Text] [Related] [New Search]