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  • Title: Immunohistochemical localization of carcinoembryonic antigen (CEA) in squamous cell carcinoma of the uterine cervix: prognostic significance of localization pattern of CEA.
    Author: Toki T, Yajima A.
    Journal: Tohoku J Exp Med; 1991 Sep; 165(1):25-32. PubMed ID: 1798974.
    Abstract:
    Immunohistochemical localization of carcinoembryonic antigen (CEA) was investigated with 100 cases of invasive squamous cell carcinoma of the uterine cervix in order to evaluate the relationship of the positive pattern of CEA to the prognoses of patients with this neoplasm. Positive staining for CEA using peroxidase-antiperoxidase method was noticed in all tumors studied. The localization patterns of CEA were divided into the following four types depending on the location of CEA-positive areas in cancer nests: central type, surrounding type, diffuse type, and focal type. Survival curves based on calculation by the method of Kaplan-Meier showed that prognosis of patient was most excellent in the disease of central type, which was followed by surrounding type, diffuse type, and focal type, in this order. The survival curve for central type was significantly better than those for diffuse type and focal type (p less than 0.05) as assessed by Log rank test. In squamous cell carcinoma of the cervix, consequently, prognosis of patient might be favorable when CEA is demonstrated in the center part of cancer nests by an immunohistochemical technique.
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