These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Pyrroloisoquinoline-based tetrapeptide analogues mimicking reverse-turn secondary structures.
    Author: Landoni N, Lesma G, Sacchetti A, Silvani A.
    Journal: J Org Chem; 2007 Dec 07; 72(25):9765-8. PubMed ID: 17990894.
    Abstract:
    New pyrroloisoquinoline-based tetrapeptides were synthesized in enantiomerically pure form, and their conformational features were studied by NMR, IR, and molecular-modeling techniques. The presence of a reverse turn was observed in both structures, with the C1 stereochemistry playing a central role in determining stable conformations. In particular, all of the analyses led to the conclusion that a type II' beta-turn is mostly stabilized in tetrapeptide mimic 3a, while a typical inverse gamma-turn geometry is revealed for the diastereoisomer 3b.
    [Abstract] [Full Text] [Related] [New Search]