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  • Title: [Hypnotic effect of Chinese materia medica Cynanchum chinese in mice].
    Author: Peng XD, Yan QS, Wang R, Yang WD, Peng JZ.
    Journal: Zhongguo Zhong Yao Za Zhi; 2007 Sep; 32(17):1774-6. PubMed ID: 17992999.
    Abstract:
    OBJECTIVE: To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice. METHOD: The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test. RESULT: the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment. CONCLUSION: The extract compounds from C. chinese showed inhibitional effect on CNS.
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