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  • Title: Decreased serum-soluble TRAIL levels in patients with amyotrophic lateral sclerosis.
    Author: Iłzecka J.
    Journal: Acta Neurol Scand; 2008 May; 117(5):343-6. PubMed ID: 17995989.
    Abstract:
    OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Previously, it was showed that apoptosis may play a role in the pathomechanisms of this disease. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with proapoptotic activity in the central nervous system. The aim of the study was to measure serum TRAIL levels in patients with ALS. MATERIALS AND METHODS: The study involved 25 patients with ALS and 20 controls. Serum TRAIL levels were performed by the enzyme-linked immunosorbent method. RESULTS: Study showed that TRAIL levels were significantly decreased in the serum of patients with ALS compared with controls (P < 0.05). There was no significant correlation between serum TRAIL levels and clinical parameters of ALS (P > 0.05). CONCLUSION: A decrease in serum TRAIL levels in patients with ALS suggests that this cytokine may be implicated in the pathomechanisms of this disease.
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