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  • Title: Telomere DNA conformation change induced aggregation of gold nanoparticles as detected by plasmon resonance light scattering technique.
    Author: Huang CZ, Liao QG, Gan LH, Guo FL, Li YF.
    Journal: Anal Chim Acta; 2007 Dec 05; 604(2):165-9. PubMed ID: 17996538.
    Abstract:
    It has been reported that adsorption of uncoiled DNA (u-DNA) on the surface of gold nanoparticles (Au-NPs) can prevent the nanoparticle suspensions from aggregation even if in salt medium. Herein we report that quadruplex DNA (q-DNA), which is formed from uncoiled telomere DNA, via intramolecular hydrogen bonds in the presence of potassium ion, cannot keep Au-NPs stable, and the q-DNA/Au-NPs coexisting suspensions display aggregation tendency, giving plasmon resonance light scattering (PRLS) signals of Au-NPs. Mechanism investigations through a single point energy calculation on u- and q-structures of telomere DNA showed that q-DNA, compared with u-DNA, has a much higher surface negative charge density, symmetrical charge distribution and well self-structural stabilization, could not be adsorbed on the surface of Au-NPs.
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