These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Nucleosomes at active promoters: unforgettable loss. Author: Henikoff S. Journal: Cancer Cell; 2007 Nov; 12(5):407-9. PubMed ID: 17996642. Abstract: A variety of chromatin features have been implicated in the regulation of gene expression, including nucleosome occupancy at promoters, histone modifications and variants, and DNA methylation. In this issue of Cancer Cell, Lin and colleagues use a powerful single-molecule approach to explore the relationship between nucleosome occupancy and gene expression in cancer cells. They show that nucleosome occupancy is mostly all-or-none at the multiple start sites of the MLH1 CpG island. After demethylation by drug treatment, nucleosomes are permanently lost as transcription becomes reactivated. Thus, epigenetic maintenance of gene expression may require that promoters are maintained free of nucleosomes.[Abstract] [Full Text] [Related] [New Search]