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  • Title: [The characteristics of the embryotoxic action of kalipsol].
    Author: Bandazhevskiĭ IuI, Shimanovich AI.
    Journal: Farmakol Toksikol; 1991; 54(5):58-9. PubMed ID: 1800154.
    Abstract:
    The effect of calipsol on the course of pregnancy and the embryonal development in albino rats was studied. It was found that single injections of the drug in a dose of 200 mg/kg on the 7th or 8th day of pregnancy induced no disorders in the pregnancy course and the embryonal development. At the administration in a dose of 40.0 mg/kg on the 11th, 13th, 15th days of pregnancy calipsol was shown to exert a marked embryolethal action and at the administration on the 7th, 9th, 11th days of pregnancy in doses of 20 and 40 mg/kg increased the number of fetuses with hemorrhages into the internal organs.
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