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  • Title: Controlled clinical trial of nifedipine alone and in combination with dilazep in patients with angina pectoris.
    Author: Pandhi P, Biswas NR, Wahi PL, Sharma PL.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1991 Nov; 29(11):454-6. PubMed ID: 1800394.
    Abstract:
    The present study was performed to see if the combined treatment with nifedipine and dilazep offers any advantage over monotherapy with nifedipine alone in angina of effort. Thirty-three patients out of 40 with classical stable angina of effort completed this double-blind, randomized, parallel design comparative clinical trial. Both nifedipine alone (15-60 mg) and in combination with dilazep (50 mg) three times a day produced a significant reduction in angina attacks, consumption of nitroglycerin tablets and increased exercise tolerance. There was, however, no difference in the reduction in these parameters between the two groups. There was no significant reduction in blood pressure both systolic as well as diastolic and rate pressure product both when nifedipine was given alone and when it was given in combination with dilazep. Laboratory data did not reveal any dysfunction of liver, kidney and hemopoietic system. The results obtained show that there was no beneficial effect of adding dilazep to nifedipine therapy in the treatment of angina pectoris.
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