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  • Title: Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy.
    Author: Ganetsky M, Babu KM, Boyer EW.
    Journal: Pediatr Emerg Care; 2007 Nov; 23(11):829-31. PubMed ID: 18007217.
    Abstract:
    An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg). Propofol infusion rapidly normalized his agitation, neuromuscular hyperactivity, and autonomic instability. Confirmatory analysis demonstrated a dextromethorphan serum concentration of 930 ng/mL. Dextromethorphan can produce serotonin syndrome in the absence of another serotonergic drug.
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