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  • Title: Radical oxidative cyclization of spiroacetals to bis-spiroacetals: an overview.
    Author: Brimble MA.
    Journal: Molecules; 2004 May 31; 9(6):394-404. PubMed ID: 18007440.
    Abstract:
    The use of iodobenzene diacetate and iodine under photolytic conditions provides and efficient method for the oxidative cyclization of spiroacetals bearing an hydroxyalkyl side chain to bis-spiroacetals. An overview is provided of the use of this reaction for the synthesis of several bis-spiroacetal containing natural products such as the polyether antibiotics salinomycin and CP44,161 and the shellfish toxins, the spirolides.
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