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  • Title: Immunocytochemical demonstration of DSIP-like immunoreactivity in the hypothalamus of the rat.
    Author: Skagerberg G, Bjartell A, Vallet PG, Charnay Y.
    Journal: Peptides; 1991; 12(5):1155-9. PubMed ID: 1800953.
    Abstract:
    The distribution of delta sleep-inducing peptide immunoreactivity (DSIP-IR) was studied in the rat diencephalon. Varicose nerve fibers exhibiting DSIP-IR were found throughout the mediobasal hypothalamus, most frequently in the hypothalamic arcuate nucleus and in the adjoining median eminence and pituitary stalk. This innervation provides a basis for the involvement of DSIP in neuroendocrine regulation at the hypothalamic level. In the hypothalamus, DSIP-IR innervation was also observed close to the third ventricle and within the mamillary complex. Despite pretreatment with colchicine, no evidence of immunoreactive cell bodies containing DSIP-IR could be found.
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