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  • Title: Steroid receptors in mammary tumours of the cat.
    Author: Rutteman GR, Blankenstein MA, Minke J, Misdorp W.
    Journal: Acta Endocrinol (Copenh); 1991; 125 Suppl 1():32-7. PubMed ID: 1801501.
    Abstract:
    The capacity of steroidal regulatory influence on benign and malignant mammary tissue in cats was investigated. Estrogen, progestin, and (in some cats) androgen receptor levels in the cytosol were measured by a multiconcentration dextran-coated charcoal method in non-affected mammary tissue (NAMT) and in benign and malignant mammary lesions from 34 cats. Receptor levels less than 5 fmol/mg protein were considered negative. Since 3 out of 4 NAMT samples had low-positive estrogen receptor and progestin receptor levels, we considered specimens in which tumour cells were intermeshed with NAMT separate from "pure" tumour specimens. The variation in estrogen receptor expression between the different tissues was moderate, there being 9/17 malignant lesions (without NAMT) estrogen receptor+ as compared with 6/6 benign lesions (without NAMT) (p less than 0.05). The variation in progestin receptor expression was greater (p less than 0.02), with only 5/17 malignant lesions-(without NAMT) progestin receptor+ as compared with 6/6 benign lesions (without NAMT). The difference in progestin receptor levels between these 2 groups was also statistically significant. In 5 cats metastases were also assayed and 2 had a low-positive estrogen receptor level, whereas 1 had a low-positive progestin receptor level. Two of 9 malignant lesions (without NAMT) had positive androgen receptor levels. Comparison of the steroid receptor expression of human and feline mammary cancer indicates that estrogen receptor and progestin receptor levels are lower in the latter. This may indicate that loss of steroid hormone dependency occurs at an earlier stage of the disease in feline mammary cancer than in human breast cancer.(ABSTRACT TRUNCATED AT 250 WORDS)
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