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  • Title: Probing the distance between the two binding sites of hirudin for its interaction with the active site and the fibrin(ogen)-binding site of alpha-thrombin.
    Author: Wagner U, Schmitz T, Otte M, Dodt J.
    Journal: Biomed Biochim Acta; 1991; 50(4-6):707-10. PubMed ID: 1801747.
    Abstract:
    The interaction of delta (Ser50)-hirudin with alpha-thrombin has been investigated. Deletion of Ser50 of r-hirudin caused a 2.7 fold increase of the Ki for its complex with alpha-thrombin. Determination of the rate constants kon and koff for complex formation showed that this effect was mainly due to a change in koff.
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