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  • Title: Metalloendopeptidase activity in urine of rodents.
    Author: Beynon RJ, Flannery AV, Macadam GC.
    Journal: Biomed Biochim Acta; 1991; 50(4-6):795-7. PubMed ID: 1801757.
    Abstract:
    The brush border membrane of mice and rats contains a phosphoramidon-insensitive metalloproteinase, meprin (neutral endopeptidase-2; NEP-2). The role of meprin is unknown, but we have shown that urine from these species contains insulin B chain degrading activity that is due to a phosphoramidon-insensitive metalloendopeptidase. By enzymic and immunological criteria, it is likely that this activity is due to meprin, and introduces the possibility that this enzyme may have a role in urinary function.
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